Orthopedia Homeodomain Protein Is Essential for Diencephalic Dopaminergic Neuron Development
نویسندگان
چکیده
منابع مشابه
Orthopedia Homeodomain Protein Is Essential for Diencephalic Dopaminergic Neuron Development
Neurons that produce dopamine as a neurotransmitter constitute a heterogeneous group involved in the control of various behaviors and physiology. In mammals, dopaminergic neurons are found in distinct clusters mainly located in the ventral midbrain and the caudal forebrain [1]. Although much is known about midbrain dopaminergic neurons, development of diencephalic dopaminergic neurons is poorly...
متن کاملThe TALE homeodomain protein Pbx2 is not essential for development and long-term survival.
Pbx2 is one of four mammalian genes that encode closely related TALE homeodomain proteins, which serve as DNA binding partners for a subset of Hox transcription factors. The expression and contributions of Pbx2 to mammalian development remain undefined, in contrast to the essential roles recently established for family members Pbx1 and Pbx3. Here we report that Pbx2 is widely expressed during e...
متن کاملSpecification of hypothalamic neurons by dual regulation of the homeodomain protein Orthopedia.
In the developing hypothalamus, a variety of neurons are generated adjacent to each other in a highly coordinated, but poorly understood process. A critical question that remains unanswered is how coordinated development of multiple neuronal types is achieved in this relatively narrow anatomical region. We focus on dopaminergic (DA) and oxytocinergic (OT) neurons as a paradigm for development o...
متن کاملDisruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety
OBJECTIVE Genetic studies in obese rodents and humans can provide novel insights into the mechanisms involved in energy homeostasis. METHODS In this study, we genetically mapped the chromosomal region underlying the development of severe obesity in a mouse line identified as part of a dominant N-ethyl-N-nitrosourea (ENU) mutagenesis screen. We characterized the metabolic and behavioral phenot...
متن کاملTranscriptional control of midbrain dopaminergic neuron development.
Although loss of midbrain dopaminergic neurons is associated with one of the most common human neurological disorders, Parkinson's disease, little is known about the specification of this neuronal subtype. Hence, the recent identification of major transcriptional determinants regulating the development of these neurons has brought much excitement and encouragement to this field. These new findi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2007
ISSN: 0960-9822
DOI: 10.1016/j.cub.2007.04.003